Leishmaniasis is a zoonosis caused by the protozoan of the genus Leishmania, which affects both humans and animals through a phlebotomist. After malaria and lymphatic filariasis, leishmaniasis is the third most common disease on a global scale. Leishmania infantum is the species spread in the European continent and the Mediterranean basin. In Italy, from the hilly coastal areas and major islands, the infection has spread to many pre-Alpine areas and northern Italy.
Technologies
In this section it is possible to view, also through targeted research, the technologies inserted in the PROMO-TT Database. For further information on the technologies and to contact the CNR Research Teams who developed them, it is necessary to contact the Project Manager (see the references at the bottom of each record card).
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Direct quantification of the percentage of arabica in roasted and ground coffee blends of arabica/robusta by High Resolution Nuclear Magnetic Resonance spectroscopy (NMR), in solution and multivariate statistical analysis. Particularly, the metabolites content present in water extracts of coffee is analyzed and compared with NMR data of our database.
The Biocrystal Facility, a large multidisciplinary laboratory established at the Institute of Molecular Biology and Pathology (IBPM) of CNR, in collaboration with the Biochemistry Department of Sapienza University aims at supporting the italian scientists and the pharmaceutical companies in the research to find new drug and vaccine against the endemic and epidemic diseases through structure-based drug design.
The dramatic global health emergency due to the SARS-CoV-2 pandemic requires new diagnostic devices capable of identifying the presence of virus particles in patient biological samples. In this direction, the development of an innovative low-cost test, which provides the result within a few minutes, which is reproducible and which can reveal the direct presence of even a few viral particles, would be of fundamental importance for the monitoring and containment of the pandemic.
The compact-GC platform is a MEMS-based analytical module for the purge&trap pre-concentration and (gas)-chromatographic separation of a sample. The two analytical MEMS (pre-concentrator and GC column) are interconnected by means of a MEMS microfluidic manifold. The microfluidic manifold interconnects the analytical MEMS, but it also acts as injector through the integrated micro-valves.
CNR-ISTEC develops geopolymer composites for thermostructural applications, such as: self-supporting cavities; thermal and acoustic insulation; thermal and fire barriers; high temperature coatings and damping; molds and cores for foundry; foams and refractory linings. Geopolymers are chemically bonded materials at T <300 ° C. Being inorganic polymers without water in the structure, they tolerate high temperatures: they are incombustible, do not emit gas or fumes and do not explode.
Coupled Stirling Engine/Fluidized Bed Combustor for micro-Distributed energy production from Biomass
A distributed micro-cogeneration system has been developed for continuous and programmable autonomous production of thermal (between 25 and 70 kWth) and electrical (between 5 and 10 kWel) energy starting from heterogeneous biomasses.
The virtual dynamic docking, carried out in the MOLBD3 lab of the Institute of Biophysics, allows the identification of new drugs through the structural information deriving from the study of target proteins, responsible for some human pathologies. In particular, we screen drugs or small molecules (commercial/own libraries) against known protein sites, surface cavities, surfaces of protein-protein interactions (fixed/rigid hotspots) or structural transition states (dynamic hotspots).
Our innovative proposal involves an educational robotics training program, resulting from an experimental research that combines traditional educational approaches with the utilization of robotics. Specifically, the educational robot Thymio, developed by EPFL, serves as a facilitator in the learning process to enhance School Readiness.
We propose a portable chemical analysis system capable of identifying chemical substances at trace concentrations (sub-ppm), even in case of a complex matrix of interfering species.
We developed a procedure aimed at simultaneously treating thousands of C.elegans model organisms, from eggs to old adult, in liquid, in 96- or 384-well plates. This procedure can be used to perform drug and toxicological screening of millions of compounds, in very small volumes and on millions of animals. Thanks to easy handling, semi-automatic analysis can be performed using plate readers or High Content Screening instruments.
In the last years, hop culture has spread throughout Italy, and the vegetative biomass disposal, after harvesting of cones, used for beer production, became a serious problem for hop growers. Hop plant contains in all parts, cones, shoots, leaves and roots, bioactive compounds, with proven and important antiviral, antibacterial and antioxidant properties.
Our idea come from the improving of the traceability technique in agro-food fisheries industries through the application of omics technologies in microbiota studies. These latter would be capable of exploiting the huge pool of biological molecules contained in fishery resources (e.g. nucleic acids, proteins, metabolites) and use them as a powerful tools for the identification and reconstruction of fishery history, from the sea to the table.
In the last years, genetics played a strategic role in the identification of therapeutic targets for complex diseases. Genetic studies identified thousands of variants contributing to disease onset and/or to the influence of measurable features (phenotypes) impacting health. The mechanism of action by which they modulate diseases and phenotypes is still unknown for the vast majority.
Detection devices for the presence of molecules of interest (analytes) enjoyed a renewed burst with the introduction of biological components (biosensors). Their high specificity is often used in various fields, from environmental monitoring and biomedicine to the protection and promotion of agri-food products. However, the high cost of production and the lack of compatibility with mass sampling (high-throughput) sometimes limit their use.