Technologies

In this section it is possible to view, also through targeted research, the technologies inserted in the PROMO-TT Database. For further information on the technologies and to contact the CNR Research Teams who developed them, it is necessary to contact the Project Manager (see the references at the bottom of each record card).

Displaying results 1 - 12 of 12

# Record card
98
Description

Leishmaniasis is a zoonosis caused by the protozoan of the genus Leishmania, which affects both humans and animals through a phlebotomist. After malaria and lymphatic filariasis, leishmaniasis is the third most common disease on a global scale. Leishmania infantum is the species spread in the European continent and the Mediterranean basin. In Italy, from the hilly coastal areas and major islands, the infection has spread to many pre-Alpine areas and northern Italy.

Thematic areas
Energy and environmental sustainability / Ecology & Biodiversity
Energy and environmental sustainability / Renewable sources
Bioeconomy
Chemicals & Physics / Organic substances
Health & Biotech / New therapies
Health & Biotech / Development of new drugs
# Record card
27
Description

The dramatic global health emergency due to the SARS-CoV-2 pandemic requires new diagnostic devices capable of identifying the presence of virus particles in patient biological samples. In this direction, the development of an innovative low-cost test, which provides the result within a few minutes, which is reproducible and which can reveal the direct presence of even a few viral particles, would be of fundamental importance for the monitoring and containment of the pandemic.

Thematic areas
Health & Biotech / Micro and nanotechnology related to biological sciences
ICT & Electronics / Sensor/multi-sensor technology, instrumentation
Health & Biotech / Bio-medicals
Health & Biotech / Diagnostic kits
ICT & Electronics / Big Data
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
Health & Biotech / Biosensors
# Record card
31
Description

The assessment of bio-humoral markers beyond clinical evaluation would allow a more comprehensive pheno/endotyping of patients affected by chronic inflammatory diseases. Therapy personalization would require a profile of the mediators that are relevant in the disease pathogenesis and that well correlate with prognosis. Currently, the measurement of multiple biomarkers is not included in patient evaluation because it has high costs,  requires centralized laboratories, experienced personnel and bulky equipment and is time-consuming.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Biosensors
# Record card
65
Description

The platform HistoPlat implies the development and validation of a mathematical algorithm, potentially combinable with an image analysis software, that, through a multiparametric approach including the immunohistochemical analysis of both expression and localization of multiple markers, allows the histopathologist or oncologist to optimize the diagnosis and prognosis, and to predict the clinical response to therapies directed towards validated and/or innovative molecular targets, also taking into account the individual variability of each pati

Thematic areas
Health & Biotech / New therapies
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
# Record card
54
Description

In the last years, hop culture has spread throughout Italy, and the vegetative biomass disposal, after harvesting of cones, used for beer production, became a serious problem for hop growers. Hop plant contains in all parts, cones, shoots, leaves and roots, bioactive compounds, with proven and important antiviral, antibacterial and antioxidant properties.

Thematic areas
Bioeconomy
Additive and advanced industrial manufacturing / Packaging
Agrifood / Agriculture
Agrifood / Nutrition & health
Agrifood / Food quality & safety
Chemicals & Physics / Subtainable substances and green chemistry
Energy and environmental sustainability / Waste management
Health & Biotech / Care, Hygiene, Cosmetics
# Record card
16
Description

Detection devices for the presence of molecules of interest (analytes) enjoyed a renewed burst with the introduction of biological components (biosensors). Their high specificity is often used in various fields, from environmental monitoring and biomedicine to the protection and promotion of agri-food products. However, the high cost of production and the lack of compatibility with mass sampling (high-throughput) sometimes limit their use.

Thematic areas
ICT & Electronics / Sensor/multi-sensor technology, instrumentation
Health & Biotech / Smart Devices for Health and Wellness
Agrifood / Nutrition & health
Agrifood / Food quality & safety
Health & Biotech / Biosensors
Energy and environmental sustainability / Pollution treatment (air, soil, water)
Health & Biotech / Micro and nanotechnology related to biological sciences
Energy and environmental sustainability / Sensory
Health & Biotech / Diagnostic kits
# Record card
63
Description

Integrative omics has posed new challenges in modern precision medicine, particularly in oncology, including i) the identification of new tumor markers for early, precise, and non-invasive diagnostics, and ii) the discovery of innovative molecular targets for therapeutic applications. Our studies on medulloblastoma, a highly malignant childhood tumor, have contributed to identifying RNA molecules that meet these criteria.

Thematic areas
Health & Biotech / New therapies
# Record card
15
Description

We have identified the presence of the poorly characterized precursor proNGF-A in human tissues, deposited its coding nucleotide sequence (GenBank MH358394) and demonstrated its neuroprotective and neurotrophic activity in vitro and in vivo. We inserted mutations into the native molecule, identified through computational analysis, which allow proNGF-A production by eukaryotic expression systems, through a method currently validated on a laboratory scale.

Thematic areas
Health & Biotech / Development of new drugs
# Record card
33
Description

Severe asthma or chronic obstructive pulmonary disease (COPD) are nowadays associated with a poor response to corticosteroids which led to the use of high-dose with consequent improved onset of side effects. The use of nanotechnologies can represent an innovative approach for the effective treatment of both asthma and COPD. The development of new nano-formulations involving the use of nanomaterials and specifically tailored to be inhaled offers numerous advantages over conventional inhaled dosage forms.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Nanomedicine
Health & Biotech / Development of new drugs
# Record card
24
Description

Combinations of several enzymes in a production chain are preferred to “first generation” enzymatic processes (where the "single reaction - single enzyme" principle was followed), for the synthesis of compounds with high added value starting from simple and cheap substrates. An important requirement for obtaining control in "cascade enzymatic reactions" is the ability to deliver from one biocatalyst to the next one the various intermediates, limiting as much as possible the diffusion of the latter in the solvent.

Thematic areas
Materials / Processes of production & treatment of materials
Agrifood / Agriculture
Agrifood / Nutrition & health
Health & Biotech / Development of new drugs
Health & Biotech / Care, Hygiene, Cosmetics
Energy and environmental sustainability / Pollution treatment (air, soil, water)
Health & Biotech / Micro and nanotechnology related to biological sciences
Chemicals & Physics / Agro chemicals
Chemicals & Physics / Inorganic substances
Chemicals & Physics / Organic substances
Chemicals & Physics / Special chemicals
Chemicals & Physics / Subtainable substances and green chemistry
Materials / Plastics, polymers
# Record card
87
Description

SITODIET is an innovative software that supports a translational approach to health’s state. It integrates various sources of physiological, behavioral, and psychological data to reduce the risks associated with the onset of lifestyle-related diseases (primary prevention), to support health professionals in early diagnosis (secondary prevention) or to manage the personalized therapy’s patient (tertiary prevention). SITODIETcollects data automatically, through actigraphy tools, as wristband or smartwatch, or manually

Thematic areas
ICT & Electronics / Big Data
Agrifood / Nutrition & health
Health & Biotech / Smart Devices for Health and Wellness
ICT & Electronics / Artificial Intelligence
ICT & Electronics / IT and Telematics applications