Technologies

Bivalve mollusc shells are made mainly of CaCO₃ (ca 95%), with a small fraction of organic material. If from these shells this mineral is retrieved, they could become a renewable and sustainable “mine” of a “blue” CaCO₃. Bivalve mollusc shells, also after the removal of the animal flesh, maintain a certain quantity of organic substances, part in the muscle and part in the shell.

B-ME developed the first thermoplastic composite electrode film based on bio-derived and biodegradable polyesters and carbon nano-fibers. It is metal-free, highly electrically conductive and possess good thermo-mechanical properties, a challenging combination of three features in a single product. This is the first-of-its-kind product, as, to the best of our knowledge, no thermoplastic biobased electrode film has been effectively produced and used so far.

The development of functional foods is often limited by industrial manufacturing processes, for example, for the production of baked foods, the use of high cooking temperatures causes denaturation of proteins, destruction of vitamins, alteration of fatty acids, etc. The protection of these components is essential in the production of gluten-free foods as they are generally poor in proteins and vitamins.

The technology based on cell or tissue cultures is very useful for the production of bioactive compounds. These molecules, depending on the class they belong to, can be used in the food, pharmaceutical and cosmetic industry. In particular, the developed technology is addressed to the optimization of bioactive compounds in plant cell/tissue cultures having the biosynthetic pathway of the compound of interest.

Mirrors for space applications, besides featuring suitable optical properties, should be light, resistant to mechanical stresses, and unsensitive to light-shadow thermal cycling. The standard optical materials easily fulfill optical and thermal requirements, but are fragile, and the mirrors must be thick (typically 1/6 of the diameter). For this reason they are heavy, and the only available solution is to lighten them, by removing material from the back side, still preserving the necessary mechanical robustness and optical quality.

The object of the technology is the development of a transferable methodology from the laboratory scale to the pilot scale to be validated in the industrial setting for the treatment of basic waste of natural polymers of agro-food or manufacturing industry.

Recently, nanoparticles and nanovesicles have been investigated as potential approaches for the treatment of neurodegenerative diseases. In particular, in the Biotech sector an increasingly deeper penetration of new treatment models and biological drugs based on cellular, subcellular and vesicle therapies is expected. The patent is based on the production of Myelin-based nanoVesicles (MyVes) produced by microfluidics, starting from myelin extracted from brain tissue. These vesicles find two major fields of applications as potential drugs or as supplements/nutraceuticals.

We have identified compounds that show a neuroprotective action in vivo, in models of neurodegenerative diseases (e.g. SMA, Parkinson, Alzheimer, Huntington) in the model organism C. elegans. These compounds consist of: mixtures of 22 natural extracts, 15 natural molecules and 11 synthetic molecules.

Design and testing of neoproteins with optimized nutritional value, according to needs, avoiding their degradation - thus maintaining a high production yield - and aggregation (which could make them indigestible). Neoproteins are produced and characterized in plant systems as bioreactors. We have already created zeolin, formed by the fusion of a bean seed protein with a portion of a maize seed protein.

Combinations of several enzymes in a production chain are preferred to “first generation” enzymatic processes (where the "single reaction - single enzyme" principle was followed), for the synthesis of compounds with high added value starting from simple and cheap substrates. An important requirement for obtaining control in "cascade enzymatic reactions" is the ability to deliver from one biocatalyst to the next one the various intermediates, limiting as much as possible the diffusion of the latter in the solvent.

The technology concerns planar optical antennas composed of thin metal films and dielectric materials for the efficient direction of the light emitted by light sources, such as fluorescent molecules and bio-markers. They consist of a reflector layer, adjacent to the substrate, and a director, semi-reflective, between which the emitter is positioned, integrated into a homogeneous dielectric layer.

The proposing team that works at CNR ISTEC has recently patented a technology for the production of the Smart Polycrystals (SP), i.e. transparent YAG-based ceramic polycrystals (Y₃Al₅O₁₂) variably doped with rare earths ions and transition metals ions. The SPs solve the problem of the reduction of the efficiency in the solid state laser systems caused by the inhomogeneous heating of the single crystals during the emission process.

Environmental contamination is a prominent topic. Where the exposure to contaminants such as heavy metals (HMs) or polycyclic aromatic hydrocarbons (PAHs) is greater, the incidence of chronic degenerative diseases, such as oncologic, is increased. Scientific evidence reports that some phytochemicals are able to interact with HMs and PAHs by interfering with their cellular metabolism, inhibiting their cytotoxic mechanisms or helping to reduce tissue concentrations.

Polymer development is approaching to a new stage of advancement in which new functionalities especially in combination with conductive polymers and nanomaterials are more effective. In this context the study of new composites is the key to enable the development of disruptive technologies as additive manufacturing. Increasing electrical conductivity open the way to a new class of objects to be prototyped rapidly at low cost with a high level of customization.

Our team can develop low-cost ultra-flexible sensors integrated on plastic substrate for volatile organic compounds (VOCs) and gas detection. These devices combine scalable fabrication technologies, implementing active materials such as nanostructured metal oxides or stack of nanostructures decorated with metal nanoparticles, thus enabling a high sensitivity (in the range of hundreds of ppb). These devices can be applied to numerous industrial and commercial sectors and they can be embedded in systems that are more sophisticated.