Technologies

The proposed system is based on a high-resolution electrocardiograph in which the electrodes are positioned on maternal abdomen. The acquired signals are processed using a completely unsupervised software for fetal ECG extraction based on independent component analysis, maternal ECG canceling and a quality index optimization. The electrocardiograph is constituted by a light-weight and light-dimension portable unit, which acquires the signals and transmit them to a computer where the analysis software runs.

This is a high-throughput sequencing based method to map euchromatin and heterochromatin accessibility. The method is based on the sequential extraction of distinct nuclear fractions containing: soluble proteins (S1 fraction); the surnatant obtained after DNase treatment (S2 fraction); DNase-resistant chromatin extracted with high salt buffer (S3 fraction); and the most condensed and insoluble portion of chromatin, extracted with urea buffer that solubilizes the remaining proteins and membranes (S4 fraction).

SITODIET is an innovative software that supports a translational approach to health’s state. It integrates various sources of physiological, behavioral, and psychological data to reduce the risks associated with the onset of lifestyle-related diseases (primary prevention), to support health professionals in early diagnosis (secondary prevention) or to manage the personalized therapy’s patient (tertiary prevention). SITODIETcollects data automatically, through actigraphy tools, as wristband or smartwatch, or manually

This technology is based on an algorithm able to provide the probability of being asthmatic with high accuracy. This probability is based on the evaluation of respiratory function and, specifically, of forced expiratory vital capacity in the first second (FEV₁), in resting conditions, and 20 minutes after administration of a bronchodilator drug.

The technology is intended to face the main problems of transmucosal dental implants, such as peri-implant mucositis, peri-implantitis and epithelial downgrowth. The strategy foresees the development of a surface able to favor soft tissues growth (gum sealing), limit at the implant collar these tissues, reduce bacterial adhesion and eventually have an antibacterial action.

We present a new concept of ultra-compact, configurable and implantable brain computer interface (BCI). The device can be applied to monitor or stimulate, with high temporal and spatial accuracy, neural activity of the brain. It allows implementation of closed-loop algorithms in real time applications. The system can be also used in vitro to monitor or induce cell growth or as tDCS tool. The system can be customized (microelectrodes materials and shapes) to guarantee the best solution for the specific application.

IMM has developed tactile sensors for the detection of objects and surface and for the handling of objects with humanoid robots (e-skin). These devices can be integrated on ultra-flexible and high conformable substrates and they can be used for multiple applications: 1) for a correct interaction with objects distributed in complex environment; 2) for a safe short-range interaction between humanoid robot and humans; 3) for fabricating smart wearables for the detection of biometric parameters (e.g. heartbeat); 4) for remotely control rovers with wearable gadgets.

We present a technology for the multiscale isolation (analytical-laboratory-production) of Extracellular Vesicles (VE), which overcomes the limitations of the currently available methods. As opposed to traditional "affinity-based" systems that exploit antibodies, our technology represents a radical paradigm shift in the development of affinity probes for vesicles, i.e.

Safe, efficient and specific nano-delivery systems are increasingly needed for precision and regenerative medicine and targeted therapies (e.g. anticancer and antimicrobial therapies), as well as for  the cosmetic and nutraceutical sectors’ applications. Despite the appreciable success of synthetic nanovectors, like for example liposomes, their clinical and market application is hampered by some limitations: • large scale production, • low cost production • intrinsic toxicity • limited cellular uptake • limited consumer acceptance.

VOLIS is an online platform that contains various tests for assessing Italian Sign Language (LIS) comprehension skills in signing children, from 4 to 11 years of age. The consequences of some difficulties such as deafness, cognitive impairments and autism spectrum disorder may affect learning, social interaction and broad communicative skills. The use of LIS may support children that have difficulties in acquiring and using a using spoken languages.

Environmental monitoring is a rapidly growing field, both in academia and industry. The use of wearables for environmental monitoring is a promising technique, as it allows data to be collected continuously and comprehensively. The main problem with using wearables for environmental monitoring is the size and weight of the system, as well as the high degree of specialization required to develop a fully functional device.