AIDD is an integrated tool and a radically new way to discovery new drugs for neurodegenerative diseases (Alzheimer’s, Epilepsy, Ageing, etc.).
Technologies
In this section it is possible to view, also through targeted research, the technologies inserted in the PROMO-TT Database. For further information on the technologies and to contact the CNR Research Teams who developed them, it is necessary to contact the Project Manager (see the references at the bottom of each record card).
Displaying results 1 - 15 of 38
The technology we participate to develop, called "Zinc-Finger Artificial Transcription Factors (ZF-ATFs)", allows to design, realize and select artificial genes coding for proteins capable of recognizing and binding "potentially" any DNA sequence. We used ZF-ATF technology to reprogram the expression of "beneficial" genes capable of efficiently counteracting the negative effect of mutated genes related to rare diseases.
B-ME developed the first thermoplastic composite electrode film based on bio-derived and biodegradable polyesters and carbon nano-fibers. It is metal-free, highly electrically conductive and possess good thermo-mechanical properties, a challenging combination of three features in a single product. This is the first-of-its-kind product, as, to the best of our knowledge, no thermoplastic biobased electrode film has been effectively produced and used so far.
The present invention relates to a gamma camera for intracavitary use, which is widely used in the field of radio-guided surgery (intra-operative and laparoscopic and robotic-assisted) for the localisation of lymph nodes and tumours and/or other pathologies. The aim of the present invention is to make available an intraoperative tool able to overcome the drawbacks of the present known art.
The assessment of bio-humoral markers beyond clinical evaluation would allow a more comprehensive pheno/endotyping of patients affected by chronic inflammatory diseases. Therapy personalization would require a profile of the mediators that are relevant in the disease pathogenesis and that well correlate with prognosis. Currently, the measurement of multiple biomarkers is not included in patient evaluation because it has high costs, requires centralized laboratories, experienced personnel and bulky equipment and is time-consuming.
The portable device is intended to assess exposure to electromagnetic fields produced by an MRI equipment. The device (dosimeter) allows to improve the analysis and study of the problems related to the exposure of the operators, starting from the technical-scientific aspects related to the exposure, also allowing to create a manual of best practices as well as to improve the professional training of operators.
The virtual dynamic docking, carried out in the MOLBD3 lab of the Institute of Biophysics, allows the identification of new drugs through the structural information deriving from the study of target proteins, responsible for some human pathologies. In particular, we screen drugs or small molecules (commercial/own libraries) against known protein sites, surface cavities, surfaces of protein-protein interactions (fixed/rigid hotspots) or structural transition states (dynamic hotspots).
Inert biomedical devices with modular load-bearing function designed with peculiar multi-domain composite microstructures. The reference compositional system is Zirconia-Alumina with a prevailing overall composition of customizable zirconia or alumina. Examples of devices are 3D structures consisting of parts with differentiated functional properties, due to different composition/microstructure/architecture, and further functionalizable ex-post to favor and improve the stabilization of the implantation by newly formed bone in superior quantity and quality.
We propose a portable chemical analysis system capable of identifying chemical substances at trace concentrations (sub-ppm), even in case of a complex matrix of interfering species.
Anthocyanins are antioxidant polyphenolic pigments produced by plants that are widely used in the food, cosmetic and pharmaceutical industries. The technology allows to obtain in a short time potato cell lines in which the production of highly acetylated and highly complex anthocyanins is increased in addition to other antioxidant polyphenolic compounds. The obtained cellular lines have a high production efficiency, comparable to the extraction of berries, but with the advantage of having an on-demand production which is not limited to seasonality.
Our idea come from the improving of the traceability technique in agro-food fisheries industries through the application of omics technologies in microbiota studies. These latter would be capable of exploiting the huge pool of biological molecules contained in fishery resources (e.g. nucleic acids, proteins, metabolites) and use them as a powerful tools for the identification and reconstruction of fishery history, from the sea to the table.
The herein described technology aims at the development of a platform of injectable hydrogels for application as drug carriers for localized delivery or in the regenerative medicine field. The use of ad-hoc synthesized poly(ether urethane)s (PEUs) as hydrogel forming materials is a common property which characterizes all the systems belonging to this platform.
This technology concerns the development of new eco-sustainable UV physical/mineral filters with the aim of offering important innovations per the cosmetic sector. This, encouraged by European initiatives in the Green-Deal context, is constantly looking for new components with improved protection of the human health and the environment.
Mirrors for space applications, besides featuring suitable optical properties, should be light, resistant to mechanical stresses, and unsensitive to light-shadow thermal cycling. The standard optical materials easily fulfill optical and thermal requirements, but are fragile, and the mirrors must be thick (typically 1/6 of the diameter). For this reason they are heavy, and the only available solution is to lighten them, by removing material from the back side, still preserving the necessary mechanical robustness and optical quality.
WembraneX is an Italian start-up born with the ambition to make a significant contribution to UN Sustainable Goal 6 - Ensure Access to Clean Water and Sanitation for all by 2030.