Technologies

Recently, it has been demonstrated that Raman spectroscopy can play a fundamental role in assisting the work of the anatomopathologist by allowing classification of oncological samples with practically 100% accuracy in oncological diagnosis.

This is a high-throughput sequencing based method to map euchromatin and heterochromatin accessibility. The method is based on the sequential extraction of distinct nuclear fractions containing: soluble proteins (S1 fraction); the surnatant obtained after DNase treatment (S2 fraction); DNase-resistant chromatin extracted with high salt buffer (S3 fraction); and the most condensed and insoluble portion of chromatin, extracted with urea buffer that solubilizes the remaining proteins and membranes (S4 fraction).

Environmental contamination is a prominent topic. Where the exposure to contaminants such as heavy metals (HMs) or polycyclic aromatic hydrocarbons (PAHs) is greater, the incidence of chronic degenerative diseases, such as oncologic, is increased. Scientific evidence reports that some phytochemicals are able to interact with HMs and PAHs by interfering with their cellular metabolism, inhibiting their cytotoxic mechanisms or helping to reduce tissue concentrations.

The substitution of fossil derived monomers in thermosetting resins is a very important point to look at to face environmental impact issues related with the use of traditional resins. The research group set up a protocol for the preparation of thermosetting resins starting from vegetable oils with different composition to substitute the petroleum-based monomers. The materials obtained in this way have a bio-based carbon content higher than 80%.