Technologies

The virtual dynamic docking, carried out in the MOLBD3 lab of the Institute of Biophysics, allows the identification of new drugs through the structural information deriving from the study of target proteins, responsible for some human pathologies. In particular, we screen drugs or small molecules (commercial/own libraries) against known protein sites, surface cavities, surfaces of protein-protein interactions (fixed/rigid hotspots) or structural transition states (dynamic hotspots).

The working principle of VTTJ is extremely simple. Two parts (at least one with tube shape) are screwed one into the other with a mechanical interference that creates a metallic seal. One part presents a cylindrical slot, the other presents a conical ring, whose diameter is slightly larger than the one of the cylindrical slot. When the two parts are screwed together, a plastic deformation occurs in the mechanical interference region.