Nanoparticles

The technology we have developed consists of a method capable of modulating the expression of specific target genes in deep-tissue cells from an exogenous signal of high safety and precision. The present invention is composed by: 1. a nanoparticle capable of converting the ultrasonic signal into a chemical signal: 2. an energy system, capable of stimulating the nanoparticle to produce Reactive Oxygen Species (ROS), and 3.

Flow technologies for the synthesis of chemical intermediates have great potential at the industrial level and the synthesis of nanoparticles (NPs) can speed up the development of new products. In this context, we could find the technology for the synthesis of NPs. The NPs (Au, Ag, or Pt) are synthesized in a single step and are functionalized with polymeric stabilizers (such as PVP, PVA, PEG, or others) or with thio-glycosidic fragments.

The assessment of bio-humoral markers beyond clinical evaluation would allow a more comprehensive pheno/endotyping of patients affected by chronic inflammatory diseases. Therapy personalization would require a profile of the mediators that are relevant in the disease pathogenesis and that well correlate with prognosis. Currently, the measurement of multiple biomarkers is not included in patient evaluation because it has high costs,  requires centralized laboratories, experienced personnel and bulky equipment and is time-consuming.