Artificial transcription factors

The technology we have developed consists of a method capable of modulating the expression of specific target genes in deep-tissue cells from an exogenous signal of high safety and precision. The present invention is composed by: 1. a nanoparticle capable of converting the ultrasonic signal into a chemical signal: 2. an energy system, capable of stimulating the nanoparticle to produce Reactive Oxygen Species (ROS), and 3.

The technology we participate to develop, called "Zinc-Finger Artificial Transcription Factors (ZF-ATFs)", allows to design, realize and select artificial genes coding for proteins capable of recognizing and binding "potentially" any DNA sequence. We used ZF-ATF technology to reprogram the expression of "beneficial" genes capable of efficiently counteracting the negative effect of mutated genes related to rare diseases.