Technologies

The present invention relates to a gamma camera for intracavitary use, which is widely used in the field of radio-guided surgery (intra-operative and laparoscopic and robotic-assisted) for the localisation of lymph nodes and tumours and/or other pathologies. The aim of the present invention is to make available an intraoperative tool able to overcome the drawbacks of the present known art.

Inert biomedical devices with modular load-bearing function designed with peculiar multi-domain composite microstructures. The reference compositional system is Zirconia-Alumina with a prevailing overall composition of customizable zirconia or alumina. Examples of devices are 3D structures consisting of parts with differentiated functional properties, due to different composition/microstructure/architecture, and further functionalizable ex-post to favor and improve the stabilization of the implantation by newly formed bone in superior quantity and quality.

The platform HistoPlat implies the development and validation of a mathematical algorithm, potentially combinable with an image analysis software, that, through a multiparametric approach including the immunohistochemical analysis of both expression and localization of multiple markers, allows the histopathologist or oncologist to optimize the diagnosis and prognosis, and to predict the clinical response to therapies directed towards validated and/or innovative molecular targets, also taking into account the individual variability of each pati

In the last years, hop culture has spread throughout Italy, and the vegetative biomass disposal, after harvesting of cones, used for beer production, became a serious problem for hop growers. Hop plant contains in all parts, cones, shoots, leaves and roots, bioactive compounds, with proven and important antiviral, antibacterial and antioxidant properties.

Portable robotic device for bilateral neuromotor rehabilitation. An appropriate mechanical structure and a series of interchangeable accessories suitably designed allow the execution of various motor gestures of the upper limbs, involving different articulations and muscles. The possibility of being used with both limbs contributes to the recovery of motor coordination and facilitates the mechanism of brain plasticity. Some rotary axes the device is equipped with are motorized and sensorized.

We have identified compounds that show a neuroprotective action in vivo, in models of neurodegenerative diseases (e.g. SMA, Parkinson, Alzheimer, Huntington) in the model organism C. elegans. These compounds consist of: mixtures of 22 natural extracts, 15 natural molecules and 11 synthetic molecules.

TNBC affects around 170,000 patients worldwide each year and accounts for 15-20% of breast cancer; compared to other types of breast cancer, TNBC is more aggressive and precocious. Its diagnosis, made difficult by the existence of subtypes with different characteristics, is fundamental to establish prognosis and personalized therapy. Nucleic acid aptamers are highly selective low-molecular-weight molecules, synthesizable at low cost and easily modifiable, capable of binding and detecting tissue markers ("aptahistochemistry”). Our team has iden

Wine is one of the economically most important beverages and may be subject to fraud and mislabelling, although that there are specific and strict rules protecting its authenticity in Europe. Single Nucleotide Polymorphisms (SNPs), recently identified and characterized thanks to advances in genomics, are considered the newest type of molecular marker for grapevine identification.

Environmental contamination is a prominent topic. Where the exposure to contaminants such as heavy metals (HMs) or polycyclic aromatic hydrocarbons (PAHs) is greater, the incidence of chronic degenerative diseases, such as oncologic, is increased. Scientific evidence reports that some phytochemicals are able to interact with HMs and PAHs by interfering with their cellular metabolism, inhibiting their cytotoxic mechanisms or helping to reduce tissue concentrations.

This technology is based on an algorithm able to provide the probability of being asthmatic with high accuracy. This probability is based on the evaluation of respiratory function and, specifically, of forced expiratory vital capacity in the first second (FEV₁), in resting conditions, and 20 minutes after administration of a bronchodilator drug.