Technologies

In this section it is possible to view, also through targeted research, the technologies inserted in the PROMO-TT Database. For further information on the technologies and to contact the CNR Research Teams who developed them, it is necessary to contact the Project Manager (see the references at the bottom of each record card).

Displaying results 1 - 15 of 16

# Record card
12
Description

Current standard SPECTs, in order to achieve high resolutions, use a multi-pinholes technology that requires numerous data processing to limit the effects of image distortion. The proposed SSR-SPECT scanner, uses a parallel-hole collimator and therefore does not require numerical reprocessing of the data to obtain correct information on the images, while assuring spatial resolutions close to those of the pinholes through the acquisition of sequences of images shifted from one to another.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
# Record card
80
Description

Time-correlated single photon counting (TCSPC) is regarded as the “gold-standard” method for fluorescence lifetime measurements. However, TCSPC requires using highly sensitive detectors, not suitable for measurements under bright light conditions, thereby making the use impractical in clinical settings. The invention described here solves this problem by synchronizing the fluorescence detection with an external light source.

Thematic areas
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
Health & Biotech / Biosensors
Health & Biotech / Bio-medicals
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic kits
Health & Biotech / Bio-informatics
# Record card
69
Description

The aim of the present invention is to develop a modular scintigraphic device, with high spatial resolution, capable of creating investigation areas of various shapes and sizes, of compact form and of being used in different types of applications.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
# Record card
42
Description

The present invention relates to a gamma camera for intracavitary use, which is widely used in the field of radio-guided surgery (intra-operative and laparoscopic and robotic-assisted) for the localisation of lymph nodes and tumours and/or other pathologies. The aim of the present invention is to make available an intraoperative tool able to overcome the drawbacks of the present known art.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
# Record card
62
Description

We propose a portable chemical analysis system capable of identifying chemical substances at trace concentrations (sub-ppm), even in case of a complex matrix of interfering species.

Thematic areas
Tourism, social sciences and cultural heritage / Archeometry
Tourism, social sciences and cultural heritage / Safety and security
ICT & Electronics / Sensor/multi-sensor technology, instrumentation
ICT & Electronics / Optics & Acoustic
ICT & Electronics / Smart cities and Communities
ICT & Electronics / Robotics and control systems
ICT & Electronics / Optoacustic sensors, Optoelectronic devices
Additive and advanced industrial manufacturing / Process control and logistic
Chemicals & Physics / Separation technologies
Additive and advanced industrial manufacturing / Factory of the Future
Chemicals & Physics / Atomic and molecular spectroscopy
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Energy and environmental sustainability / Safety and security
Health & Biotech / Medical Device
Energy and environmental sustainability / Natural disasters
Energy and environmental sustainability / Pollution treatment (air, soil, water)
Energy and environmental sustainability / Sensory
Measurement tools and Standards
ICT & Electronics / Electronics and microelectronics
# Record card
72
Description

NIRS is a non-invasive technique for the human brain cortex imaging based on the measurement of the NIR light emitted by suitable optical sources placed on the patient head and backdiffused to the surface after passing through the brain tissues. NIRS monitors the percentage of oxygenated and reduced hemoglobin  in the blood, and it allows the real time functional imaging of the brain cortex also in tomographic mode (Diffuse Optical Tomography - DOT).

Thematic areas
ICT & Electronics / Sensor/multi-sensor technology, instrumentation
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
# Record card
160
Description

At IFN-CNR, in collaboration with Politecnico di Milano-Department of Physics, we have developed Raman microscopy approaches compatible with the study and characterization of biological and industrial samples. In detail, our facility houses a self-built spontaneous confocal Raman microscope with the following characteristics: two excitation lasers (660nm and 785nm), inverted microscope (Olympus IX-73) and Princeton spectrometer / CCD.

Thematic areas
Chemicals & Physics
Chemicals & Physics / Imaging & image processing
Chemicals & Physics / Atomic and molecular spectroscopy
Health & Biotech
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Biosensors
# Record card
252
Description

Extracellular vesicles produced by teratocarcinoma cells were isolated and characterized. Functional assays on glioblastoma (GBM) cell cultures showed the inhibitory effect of these vesicles on tumor cell migration, without inducing undesirable effects such as increased cell proliferation or chemotherapy resistance.

Thematic areas
Health & Biotech
Health & Biotech / Micro and nanotechnology related to biological sciences
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Nanomedicine
Health & Biotech / Development of new drugs
# Record card
15
Description

We have identified the presence of the poorly characterized precursor proNGF-A in human tissues, deposited its coding nucleotide sequence (GenBank MH358394) and demonstrated its neuroprotective and neurotrophic activity in vitro and in vivo. We inserted mutations into the native molecule, identified through computational analysis, which allow proNGF-A production by eukaryotic expression systems, through a method currently validated on a laboratory scale.

Thematic areas
Health & Biotech / Development of new drugs
# Record card
71
Description

Recently, nanoparticles and nanovesicles have been investigated as potential approaches for the treatment of neurodegenerative diseases. In particular, in the Biotech sector an increasingly deeper penetration of new treatment models and biological drugs based on cellular, subcellular and vesicle therapies is expected. The patent is based on the production of Myelin-based nanoVesicles (MyVes) produced by microfluidics, starting from myelin extracted from brain tissue. These vesicles find two major fields of applications as potential drugs or as supplements/nutraceuticals.

Thematic areas
Health & Biotech / Micro and nanotechnology related to biological sciences
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Nanomedicine
Health & Biotech / Development of new drugs
Agrifood / Nutrition & health
# Record card
258
Description

The development of new materials with near-infrared emission (NIR, 700 – 1000 nm) represent an important target in the technological progress of innovative active components for OLED devices (including flexible ones), surveillance systems, autonomous driving, night vision sensors, fiber optic telecommunications and medical systems. In all these fields it still lacks a commercial NIR-OLED technology.

Thematic areas
Chemicals & Physics
Chemicals & Physics / Micro and nanotechnology related to physical, chemical and exact sciences
Health & Biotech
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
ICT & Electronics
ICT & Electronics / Optoacustic sensors, Optoelectronic devices
Health & Biotech / Medical Device
Energy and environmental sustainability
Energy and environmental sustainability / Environmental engineering/technologies
Chemicals & Physics / Inorganic substances
Energy and environmental sustainability / Sensory
Chemicals & Physics / Organic substances
Chemicals & Physics / Colours & dyes
Materials
# Record card
20
Description

Therapeutic strategies targeting cell cycle in cancer have in general failed in the clinic since the drugs have lacked the therapeutic index required to achieve a robust response against cancer cells with little or no cytotoxic effect on normal cells. NEK6 kinase, which is implicated in cell cycle control, has recently emerged as an attractive target for the development of novel anticancer drugs with enhanced therapeutic index.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Development of new drugs
# Record card
137
Description

With the advent of senolytic agents, capable of selectively removing senescent cells in “aged” tissues, the perception of age-associated diseases has changed from being an inevitable to a preventable phenomenon of human life. The present invention is part of this research topic with the identification of molecules with potential pro-apoptotic activity, specifically with senolytic activity. The computational approach adopted, is based on combining ligand-base and structure-based virtual screening.

Thematic areas
Health & Biotech
Health & Biotech / Micro and nanotechnology related to biological sciences
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Nanomedicine
Health & Biotech / Development of new drugs
# Record card
177
Description

Filamentous bacteriophages for size, in vivo biodistribution and easiness of engineering, are considered as natural nanoparticles. The developed technology allows the construction of bio-nanoparticles based on filamentous bacteriophages delivering proteic antigens and immunomodulating lipids. Thanks to the high content of hydrophobic residues, phage capsid proteins have high binding affinity to lipids, allowing the conjugation of immunostimulating lipids.

Thematic areas
Health & Biotech
Health & Biotech / Nanomedicine
Health & Biotech / Development of new drugs
# Record card
138
Description

We present a technology for the multiscale isolation (analytical-laboratory-production) of Extracellular Vesicles (VE), which overcomes the limitations of the currently available methods. As opposed to traditional "affinity-based" systems that exploit antibodies, our technology represents a radical paradigm shift in the development of affinity probes for vesicles, i.e.

Thematic areas
Health & Biotech
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Nanomedicine
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Regenerative Medicine
Health & Biotech / Care, Hygiene, Cosmetics
Health & Biotech / Biosensors
Health & Biotech / Micro and nanotechnology related to biological sciences
Health & Biotech / Bio-medicals
Health & Biotech / Diagnostic kits
Chemicals & Physics
Chemicals & Physics / Separation technologies