Technologies

Organotypic models of ovarian cancer are 3D models containing defined extracellular matrices, such as collagen and fibronectin, ovarian cancer cells with specific genetic/molecular characteristics, and one or more cancer-associated stromal cell types (fibroblasts, mesothelial cells, endothelial cells) to mimic specific metastatic niches of ovarian cancer (omentum, peritoneum, interstitial stroma) and the complex interactions within tumor tissues.

4Ts Game was born in ITD in 2017 to indicate a board game for teacher training, which aims to develop skills in designing collaborative learning activities. The game was originally conceived as a 'tangible' game, consisting of a board and 4 decks of paper cards which contain inputs that guide the teachers/players' design process. Subsequently the game evolved and was developed in its digital version. In this version, developed in Unity and with an underlying knowledge base in Prolog, the game is able to provide feedback to teachers regarding the design/game choices made.

A biosensor based on magnetic microspheres functionalized with a DNA-aptamer was developed for the specific biomonitoring of biological contaminants (mycotoxins) in urine.

The technology, developed by CNR-ICB, is based on an innovative bioprocess called "Caphnophilic (CO2-requiring) Lactic Fermentation (CLF)”, developed in the hyperthermophilic bacterium Thermotoga neapolitana (EP patent: EP2948556B1), which allows the production of "green" hydrogen and capture and valorization of CO2 in L -lactic acid (98% e.e.).

The Proof-of-Concept A.L.I.C.E. or "Actuators based on Light sensitive CompositE" aims at the development of innovative materials through 3D/4D printing processes and uses them as actuators in the fields of photovoltaics, concentrated solar power, thermodynamic solar, and other applications such as optical deflectors, optical microvalves, and optical switches.

Ageing characterization of Balsamic Vinegar of Modena (BVM) and Traditional Balsamic Vinegar of Modena (TBVM) by the combined use of Nuclear Magnetic Resonance spectroscopy (NMR) and multivariate statistical analysis. Our database allows to differentiate BVM from TBVM samples. Moreover, within BVMs, samples with ageing <3/>3 years can be discriminated and within TBVM, samples with ageing between 12 and 25 years as well as >25 years can be discriminated.

AIDD is an integrated tool and a radically new way to discovery new drugs for neurodegenerative diseases (Alzheimer’s, Epilepsy, Ageing, etc.).

Aliophen-XP is a highly concentrated polyphenolic composition derived from Aliophen®, a patented formulation based on malt and hops (Patent No. 102017000096298). Developed to enhance the original formulation, Aliophen-XP is produced through a specialized process that removes components potentially interfering with the biological activity of the bioactive compounds naturally extracted from malt and hops.

This innovative technology involves the use of a high-affinity, highly specific antibody that targets extracellular domains of connexin hemichannels (Cx26, Cx30, and Cx32). The antibody has been designed to reduce or inhibit the growth of brain tumors, particularly glioblastoma (GBM), and to alleviate the associated epilepsy. By blocking connexin hemichannels, the antibody interferes with pathological ATP release and other signaling mechanisms that contribute to tumor progression and neural hyperexcitability.

This proposal focuses on the preparation of biocoatings enriched with varying percentages of mint essential oil nanoparticles, followed by their application to potato tubers to limit sprouting and control the development of alkaloids, particularly solanine, a toxic substance for the body.

The proposed technology consists of a portable device for monitoring the freshness of fish, based on its smell. The device is based on a gas sensor and pattern recognition software to correlate the sensor signal to the freshness of the food. The technology is designed for its integration into domestic or industrial refrigerators.

Combined use of High-Resolution Nuclear Magnetic Resonance spectroscopy (NMR) and multivariate statistical analysis for the differentiation of PDO Parmigiano Reggiano samples according to ripening and for the differentiation of PDO Parmigiano Reggiano from “Grana type” products available on the market.

Time-correlated single photon counting (TCSPC) is regarded as the “gold-standard” method for fluorescence lifetime measurements. However, TCSPC requires using highly sensitive detectors, not suitable for measurements under bright light conditions, thereby making the use impractical in clinical settings. The invention described here solves this problem by synchronizing the fluorescence detection with an external light source.

B-ME developed the first thermoplastic composite electrode film based on bio-derived and biodegradable polyesters and carbon nano-fibers. It is metal-free, highly electrically conductive and possess good thermo-mechanical properties, a challenging combination of three features in a single product. This is the first-of-its-kind product, as, to the best of our knowledge, no thermoplastic biobased electrode film has been effectively produced and used so far.

A virtuous multi-step biorefinery platform to convert urban biowaste into valuable molecules, not disregarding renewable energy and digestate production. The strategy is based on the integration of a thermal pretreatment capable of significantly increasing the fraction of fermentable organic carbon, in order to furthermore change the status of the feedstock to become more suitable for production of a) high-value bio-based molecules, b) biomethane and c) hygienized digestate to be recycled as biofertilizer.