Organotypic models of ovarian cancer are 3D models containing defined extracellular matrices, such as collagen and fibronectin, ovarian cancer cells with specific genetic/molecular characteristics, and one or more cancer-associated stromal cell types (fibroblasts, mesothelial cells, endothelial cells) to mimic specific metastatic niches of ovarian cancer (omentum, peritoneum, interstitial stroma) and the complex interactions within tumor tissues.
Technologies
In this section it is possible to view, also through targeted research, the technologies inserted in the PROMO-TT Database. For further information on the technologies and to contact the CNR Research Teams who developed them, it is necessary to contact the Project Manager (see the references at the bottom of each record card).
Displaying results 1 - 15 of 23
4Ts Game was born in ITD in 2017 to indicate a board game for teacher training, which aims to develop skills in designing collaborative learning activities. The game was originally conceived as a 'tangible' game, consisting of a board and 4 decks of paper cards which contain inputs that guide the teachers/players' design process. Subsequently the game evolved and was developed in its digital version. In this version, developed in Unity and with an underlying knowledge base in Prolog, the game is able to provide feedback to teachers regarding the design/game choices made.
A biosensor based on magnetic microspheres functionalized with a DNA-aptamer was developed for the specific biomonitoring of biological contaminants (mycotoxins) in urine.
The technology for organic thin film transistors (OTFTs) is suitable for large area electronics, disposable electronics and "Internet of Things" applications. Circuits employing OTFTs can be realized by using very cheap printing technologies. The electrical behavior of these devices is essentially different from the behavior of silicon MOSFETs and, in order to enable circuit design, compact models specific for OTFTs are needed.
The presented technology is an electrical compact model for OTFTs that:
The Proof-of-Concept A.L.I.C.E. or "Actuators based on Light sensitive CompositE" aims at the development of innovative materials through 3D/4D printing processes and uses them as actuators in the fields of photovoltaics, concentrated solar power, thermodynamic solar, and other applications such as optical deflectors, optical microvalves, and optical switches.
AIDD is an integrated tool and a radically new way to discovery new drugs for neurodegenerative diseases (Alzheimer’s, Epilepsy, Ageing, etc.).
The Biocrystal Facility, a large multidisciplinary laboratory established at the Institute of Molecular Biology and Pathology (IBPM) of CNR, in collaboration with the Biochemistry Department of Sapienza University aims at supporting the italian scientists and the pharmaceutical companies in the research to find new drug and vaccine against the endemic and epidemic diseases through structure-based drug design.
Digital Eye is an innovative, rapid and high-precision intelligent computer vision system for the non-destructive and contactless evaluation of quality and shelf-life of whole or fresh-cut fruit and vegetables. It integrates advanced vision and artificial intelligence technologies to estimate parameters useful to evaluate the quality of fruit and vegetables, during both the harvesting phase and the cold chain.
Molecular doping (MD) is a doping method based on the use of liquid solutions. The dopant precursor is in liquid form and the material to be doped is immersed in the solution. During the immersion process, the molecule containing the dopant atom is deposited on the surface of the material forming a self-assembled monolayer, that is, ordered and compact. Through a subsequent heat treatment, the molecule decomposes and the dopant diffuses.
The virtual dynamic docking, carried out in the MOLBD3 lab of the Institute of Biophysics, allows the identification of new drugs through the structural information deriving from the study of target proteins, responsible for some human pathologies. In particular, we screen drugs or small molecules (commercial/own libraries) against known protein sites, surface cavities, surfaces of protein-protein interactions (fixed/rigid hotspots) or structural transition states (dynamic hotspots).
The insertion of executable programs within QR codes is a new enabling technology for many application contexts in everyday life. Every time Internet access is unavailable, QR code usage is limited to reading the data it contains without any possibility of interaction.
22q11.2DS(DGS) deletion syndrome is a rare and phenotypically variable multiorgan syndrome, currently without any cure. Our aim is to develop a standardized approach to formulate pharmacological products useful for clinical trials direct to prevent some serious clinical manifestations of adolescence and adulthood, such as neuropsychiatric and musculoskeletal diseases, or to eliminate or improve cardiovascular defects during embryonic development.
In the last years, genetics played a strategic role in the identification of therapeutic targets for complex diseases. Genetic studies identified thousands of variants contributing to disease onset and/or to the influence of measurable features (phenotypes) impacting health. The mechanism of action by which they modulate diseases and phenotypes is still unknown for the vast majority.
We propose a compact innovative spectroscopy system operating in the UV range. In the actual version, designed for gas, it exhibits: an aluminium tubular optical chamber (length can be adjusted; currently is 20 cm); a cheap commercial UV LED; a SiC visible blind UV detector designed and manufactured at the CNR-IMM facilities. The team developed also the electronic chain for wireless remote real time read out; while able to deal with pA current levels, it uses very cheap components and construction technology.
This invention comprises an interrogation and readout differential method for chemical sensors based on Surface Plasmon Resonances (SPR). The integration of the SPR sensing unit (chip or other), as intermediate reflecting element of a Fabry-Perot (FP) optical resonator, is the starting point for the application of this method.