The Biocrystal Facility, a large multidisciplinary laboratory established at the Institute of Molecular Biology and Pathology (IBPM) of CNR, in collaboration with the Biochemistry Department of Sapienza University aims at supporting the italian scientists and the pharmaceutical companies in the research to find new drug and vaccine against the endemic and epidemic diseases through structure-based drug design.
Technologies
In this section it is possible to view, also through targeted research, the technologies inserted in the PROMO-TT Database. For further information on the technologies and to contact the CNR Research Teams who developed them, it is necessary to contact the Project Manager (see the references at the bottom of each record card).
Displaying results 1 - 14 of 14
The portable device is intended to assess exposure to electromagnetic fields produced by an MRI equipment. The device (dosimeter) allows to improve the analysis and study of the problems related to the exposure of the operators, starting from the technical-scientific aspects related to the exposure, also allowing to create a manual of best practices as well as to improve the professional training of operators.
The virtual dynamic docking, carried out in the MOLBD3 lab of the Institute of Biophysics, allows the identification of new drugs through the structural information deriving from the study of target proteins, responsible for some human pathologies. In particular, we screen drugs or small molecules (commercial/own libraries) against known protein sites, surface cavities, surfaces of protein-protein interactions (fixed/rigid hotspots) or structural transition states (dynamic hotspots).
Our innovative proposal involves an educational robotics training program, resulting from an experimental research that combines traditional educational approaches with the utilization of robotics. Specifically, the educational robot Thymio, developed by EPFL, serves as a facilitator in the learning process to enhance School Readiness.
We developed a procedure aimed at simultaneously treating thousands of C.elegans model organisms, from eggs to old adult, in liquid, in 96- or 384-well plates. This procedure can be used to perform drug and toxicological screening of millions of compounds, in very small volumes and on millions of animals. Thanks to easy handling, semi-automatic analysis can be performed using plate readers or High Content Screening instruments.
In the last years, genetics played a strategic role in the identification of therapeutic targets for complex diseases. Genetic studies identified thousands of variants contributing to disease onset and/or to the influence of measurable features (phenotypes) impacting health. The mechanism of action by which they modulate diseases and phenotypes is still unknown for the vast majority.
It enables a systemic and evolutionary development of people, organisations and territories by overcoming the criticality of traditional approaches, which get stuck because of rationalistic reductions in complexity, as well as lack of motivation. This responds to the social sustainability needs highlighted by the UN 2030 agenda. The methodology is based on 3 pillars:
The NanoMicroFab infrastructure, support companies operating in the field of micro and nanoelectronics through the supply of materials, development of processes, design, fabrication and characterization of materials and devices. NanoMicroFab makes use of existing CNR facilities of the Institute of Microelectronics and Microsystems, the Institute of Photonics and Nanotechnologies and the Institute for the Structure of Matter and provides: • a complete line of development of devices based on wide band gap semiconductors.
Network structures that require the use of a common database are affected by the risk of processing identification data that are necessary for sharing information and updating and processing data with equal access level between the network nodes. However, this sharing could lead risks of vulnerability when identification data are exchanged between the nodes of the network. The proposed information system involves the exchange of information by encrypting the identification data with an MD5 Hashing procedure (RFC1321).
The invention concerns an apparatus for measuring the three-dimensional (3-D) sea surface elevation from moving and floating platforms. In particular, the invention consists of two or more synchronized digital video-cameras that frame, from distinct and remote points of view, a common portion of the sea surface. A triangulation process makes it possible to obtain a three-dimensional reconstruction of the sea surface from these images. The invention is particularly suitable for measuring sea waves.
This form describes a programmable, autonomous and stand-alone imaging system for the acquisition and processing of images containing subjects whose size is larger than 1cm (e.g. gelatinous zooplankton, fishes, litter, manufacts), form the seafloor or along the water column, in shallow or deep waters. It is capable to recognize and classify the image content through pattern recognition algorithms that combine computer vision and artificial intelligence methodologies.
VOLIS is an online platform that contains various tests for assessing Italian Sign Language (LIS) comprehension skills in signing children, from 4 to 11 years of age. The consequences of some difficulties such as deafness, cognitive impairments and autism spectrum disorder may affect learning, social interaction and broad communicative skills. The use of LIS may support children that have difficulties in acquiring and using a using spoken languages.
WSense provides customizable and modular real-time, bi-directional, in-situ monitoring tools capable of sending real-time alarms. It makes possible to monitor the entire water column, on areas that can scale from a few tens of square meters to hundreds or thousands of square meters depending on the number of nodes deployed as needed. The monitoring system is implemented using submarine wireless communication nodes (W-Nodes) integrated with probes to monitor various parameters.
X-ray imaging techniques can work in i) "full-field mode" in which the object to study (or part of it) is completely illuminated by the X-ray beam; ii) "scanning mode" in which an X-ray beam, focused through an opportune optics, illuminates in succession contiguous areas of the sample under examination, and the transmitted wave is measured by a detector placed at a proper distance from it. One of these X-ray scanning microscopes is available at the facility (X-ray MicroImaging, XMIL@b) of the Institute of Crystallography (CNR-Bari).