Screening platform to monitor the biological effects of compounds, nutrients and drugs on cell metabolism and health using fluorescent and bioluminescent imaging systems and measurements of relevant physiological parameters on a medium-to-large scale

# Record card
153
Thematic areas
Health & Biotech
Health & Biotech / Micro and nanotechnology related to biological sciences
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Development of new drugs
Health & Biotech / Biosensors
Agrifood
Agrifood / Nutrition & health
Agrifood / Food quality & safety
Description

To the enterprises working in the field of nutrition/nutraceutics and drug development/repositioning, we offer the know-how and state-of-the-art instrumentation of our labs to monitor multiple relevant biological parameters at the cellular level: metabolic activity, vitality, health, but also stress and toxicity. The use of advanced imaging techniques based on fluorescent/bioluminescent probes together with the availability of time-lapse acquisitions, guarantee the cutting-edge analysis of different biological parameters over time. This is indeed fundamental for the comprehension of the action that new molecules and treatments may exert on men and animals. The implementation of tissue-specific and disease-model cellular systems further extends the study of those effects on specific contexts (nutrition-related, therapeutic or tissue-specific) providing valuable pre-clinical data and scientific validation of the biologic action of the products, before they are put on the market.

Business fields
Services
Type of innovation
Service/know how innovation
Description of innovative features / Competitive advantages

The understanding of cellular responses to specific molecules/drugs/treatments is crucial to optimize their biological action, to validate their therapeutic effect, or to identify novel nutritional supplements and bioactive compounds, ahead of their distribution on the market. The implementation of cutting-edge biomedical investigations and different cellular models represents an essential innovative approach for the development of new therapies/treatments/diets aimed to satisfy the present clinical and commercial requests, including those focusing on a “personalized” care. The possibility to perform middle-to-large scale studies definitively widen the field of action of our approach, ensuring the reliability and reproducibility of the results. This approach guarantees to identify/characterize/validate the biologically relevant products with a high degree of confidence, reducing the pre-clinical testing time and facilitating therapeutic effectiveness and success on the market.

Reference market
Impacts on existing markets
Development stage
Prototype
TRL
6
7
8
Advantages
Product/process/service/technology optimization
Patentable technology
No
Patented technology
No
Publication of technology
Published
Technology validation/demonstration
Internal validation
Market positioning
Italian
European
International
Partner required
Enteprise
Private research center
Cooperation in national /european / international project

Information
For more information and/or to be put in contact with the Research Team, please contact the Project Manager:

Barbara Angelini - Project Manager
CNR - Unità Valorizzazione della Ricerca
Phone number 06.49932415
E-mail barbara.angelini@cnr.it