Technologies

A biosensor based on magnetic microspheres functionalized with a DNA-aptamer was developed for the specific biomonitoring of biological contaminants (mycotoxins) in urine.

Nowadays, to properly design and develop advanced materials capable to preserve for long times their performance under aggressive environments such as power generation plants, renewables, nuclear reactors and electronics of new generation, transport on ground and on space, aeronautics, catalysis, biomedical implants, the optimization of metallurgical processes involved is crucial.

CNR-ISTEC develops geopolymer composites for thermostructural applications, such as: self-supporting cavities; thermal and acoustic insulation; thermal and fire barriers; high temperature coatings and damping; molds and cores for foundry; foams and refractory linings. Geopolymers are chemically bonded materials at T <300 ° C. Being inorganic polymers without water in the structure, they tolerate high temperatures: they are incombustible, do not emit gas or fumes and do not explode.

The proposed technology is based on the micro-fabrication of electrodes in order to generate surface acoustic waves (SAW) with well-defined frequencies, on piezoelectric substrates. The operating principle of a surface acoustic wave sensor is linked to the variation of the characteristics of the acoustic wave that propagates on the device (e.g. wave velocity on the substrate, etc.) caused by the interaction with the environment (e.g. interaction of an analyte on the surface of the device, deformation of the substrate, etc.).

The insertion of executable programs within QR codes is a new enabling technology for many application contexts in everyday life. Every time Internet access is unavailable, QR code usage is limited to reading the data it contains without any possibility of interaction.

Method for extracting, with high yield, phycobiliproteins from cyanobacterial and/or algal biomass, obtaining aqueous extracts characterized by high concentration of pigments (4-5 mg/mL)  and a purity, at least equal to food/cosmetic grade (P≥2).

Anthocyanins are antioxidant polyphenolic pigments produced by plants that are widely used in the food, cosmetic and pharmaceutical industries. The technology allows to obtain in a short time potato cell lines in which the production of highly acetylated and highly complex anthocyanins is increased in addition to other antioxidant polyphenolic compounds. The obtained cellular lines have a high production efficiency, comparable to the extraction of berries, but with the advantage of having an on-demand production which is not limited to seasonality.

The technology based on cell or tissue cultures is very useful for the production of bioactive compounds. These molecules, depending on the class they belong to, can be used in the food, pharmaceutical and cosmetic industry. In particular, the developed technology is addressed to the optimization of bioactive compounds in plant cell/tissue cultures having the biosynthetic pathway of the compound of interest.

Mirrors for space applications, besides featuring suitable optical properties, should be light, resistant to mechanical stresses, and unsensitive to light-shadow thermal cycling. The standard optical materials easily fulfill optical and thermal requirements, but are fragile, and the mirrors must be thick (typically 1/6 of the diameter). For this reason they are heavy, and the only available solution is to lighten them, by removing material from the back side, still preserving the necessary mechanical robustness and optical quality.

The proposal concerns the development of the G.A.T.CD4 (Gliadin-activated CD4+ T cells) method which allows, in peripheral blood, the identification of CD4+ T lymphocytes reactive to toxic peptides of gliadin, the main gluten protein of cereals.

Design and testing of neoproteins with optimized nutritional value, according to needs, avoiding their degradation - thus maintaining a high production yield - and aggregation (which could make them indigestible). Neoproteins are produced and characterized in plant systems as bioreactors. We have already created zeolin, formed by the fusion of a bean seed protein with a portion of a maize seed protein.

The systems simulate, with high reproducibility, the conditions that occur in the different compartments of the gastrointestinal tracts and are promising to accurately mimic the digestive process, with the possibility to evaluate bioaccessibility and bioavailability. Moreover, the systems permit to study the synergic and reciprocal effects between the bioactive compounds characteristic of food and intestinal microbiota.

The technology concerns planar optical antennas composed of thin metal films and dielectric materials for the efficient direction of the light emitted by light sources, such as fluorescent molecules and bio-markers. They consist of a reflector layer, adjacent to the substrate, and a director, semi-reflective, between which the emitter is positioned, integrated into a homogeneous dielectric layer.

Plants can compete favorably with traditional expression systems (mammalian cells, yeasts or bacteria) to produce recombinant proteins/peptides of pharmaceutical/industrial/agrifood interest. This technology names “Plant Molecular Farming”. The CNR-IBBA research team offers the study of new strategies for the expression and optimization of recombinant proteins/peptides in plant-based systems (plant tissues, transgenic plants, plant cell culture). Our pipeline is based on the following modules:

The environment as well as the food production provide a number of both natural and synthetic compounds whose effects on human being as an organism have not yet been determined nor investigated.