Platform for the identification of potential endocrine disruptor and cytotoxic effects of natural and synthetic compounds

The environment as well as the food production provide a number of both natural and synthetic compounds whose effects on human being as an organism have not yet been determined nor investigated. Moreover, routine analysis of the substances placed in the market evaluate basic macroscopic toxic effects such as extensive morphological changes and cell death, potentially underestimating the long-term consequence of chronic exposure to pollutants, as it happened with perfluoroalkyl and polyfluoroalkyl substances (PFAS) in the Italian Veneto region. In this context, our laboratory offers its consolidated experience, instrumentation, and methodologies, acquired through years of scientific research in the field, for the analysis of the potential negative effects on the endocrine system (i.e. as endocrine disruptors) and on cell and tissue homeostasis (more classical cytotoxicity) of molecules and compounds, which may be present in natural products as well as artificially synthetized and placed in the market. Thus, the technology we propose is of utmost relevance for companies working in the field of food production, pharmaceutics, nutraceutics, innovative materials, packaging, and food safety surveillance system. Indeed, it may provide a reliable and accurate pre-commercial study and scientifically relevant validation of the biological safety of substances before placing on the market.