Technologies

In this section it is possible to view, also through targeted research, the technologies inserted in the PROMO-TT Database. For further information on the technologies and to contact the CNR Research Teams who developed them, it is necessary to contact the Project Manager (see the references at the bottom of each record card).

Displaying results 61 - 75 of 102

# Record card
20
Description

Therapeutic strategies targeting cell cycle in cancer have in general failed in the clinic since the drugs have lacked the therapeutic index required to achieve a robust response against cancer cells with little or no cytotoxic effect on normal cells. NEK6 kinase, which is implicated in cell cycle control, has recently emerged as an attractive target for the development of novel anticancer drugs with enhanced therapeutic index.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Development of new drugs
# Record card
35
Description

We have identified compounds that show a neuroprotective action in vivo, in models of neurodegenerative diseases (e.g. SMA, Parkinson, Alzheimer, Huntington) in the model organism C. elegans. These compounds consist of: mixtures of 22 natural extracts, 15 natural molecules and 11 synthetic molecules.

Thematic areas
Agrifood / Nutrition & health
Health & Biotech / Development of new drugs
Health & Biotech / Care, Hygiene, Cosmetics
# Record card
137
Description

With the advent of senolytic agents, capable of selectively removing senescent cells in “aged” tissues, the perception of age-associated diseases has changed from being an inevitable to a preventable phenomenon of human life. The present invention is part of this research topic with the identification of molecules with potential pro-apoptotic activity, specifically with senolytic activity. The computational approach adopted, is based on combining ligand-base and structure-based virtual screening.

Thematic areas
Health & Biotech
Health & Biotech / Micro and nanotechnology related to biological sciences
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Nanomedicine
Health & Biotech / Development of new drugs
# Record card
158
Description

Solid State Nuclear Magnetic Resonance spectroscopy (SSNMR) is today one of the most powerful techniques for characterizing solid and soft materials and systems. This spectroscopy allows the detailed characterization of structural and dynamic properties over large spatial (0.1-100 nm) and time (102-10-11 s) scales. Accessing these properties allows a deep knowledge of a material to be obtained and  its design and optimization to be oriented.

Thematic areas
ICT & Electronics
ICT & Electronics / Optoacustic sensors, Optoelectronic devices
ICT & Electronics / Nanotechnologies related to electronics and microelectronics
Additive and advanced industrial manufacturing
Additive and advanced industrial manufacturing / Packaging
Additive and advanced industrial manufacturing / Additive manufacturing processes and materials
Additive and advanced industrial manufacturing / Factory of the Future
Materials
Materials / Wood products
Health & Biotech
Health & Biotech / Nanomedicine
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Development of new drugs
Health & Biotech / Regenerative Medicine
Health & Biotech / Care, Hygiene, Cosmetics
Tourism, social sciences and cultural heritage
Tourism, social sciences and cultural heritage / Technologies for preservation of cultural heritage
Aerospace and Earth Science
Aerospace and Earth Science / Aeronautical technologies and avionics
Tourism, social sciences and cultural heritage / Multimedia technologies
Tourism, social sciences and cultural heritage / Archaeology
Agrifood
Agrifood / Agriculture
Agrifood / Food quality & safety
Automotive transport and logistics
Automotive transport and logistics / Vehicles
Automotive transport and logistics / Shipbuilding
Automotive transport and logistics / Innovative fuels
Chemicals & Physics
Energy and environmental sustainability
# Record card
132
Description

The systems simulate, with high reproducibility, the conditions that occur in the different compartments of the gastrointestinal tracts and are promising to accurately mimic the digestive process, with the possibility to evaluate bioaccessibility and bioavailability. Moreover, the systems permit to study the synergic and reciprocal effects between the bioactive compounds characteristic of food and intestinal microbiota.

Thematic areas
Agrifood
Health & Biotech
Agrifood / Nutrition & health
Agrifood / Food quality & safety
# Record card
24
Description

Combinations of several enzymes in a production chain are preferred to “first generation” enzymatic processes (where the "single reaction - single enzyme" principle was followed), for the synthesis of compounds with high added value starting from simple and cheap substrates. An important requirement for obtaining control in "cascade enzymatic reactions" is the ability to deliver from one biocatalyst to the next one the various intermediates, limiting as much as possible the diffusion of the latter in the solvent.

Thematic areas
Materials / Processes of production & treatment of materials
Agrifood / Agriculture
Agrifood / Nutrition & health
Health & Biotech / Development of new drugs
Health & Biotech / Care, Hygiene, Cosmetics
Energy and environmental sustainability / Pollution treatment (air, soil, water)
Health & Biotech / Micro and nanotechnology related to biological sciences
Chemicals & Physics / Agro chemicals
Chemicals & Physics / Inorganic substances
Chemicals & Physics / Organic substances
Chemicals & Physics / Special chemicals
Chemicals & Physics / Subtainable substances and green chemistry
Materials / Plastics, polymers
# Record card
177
Description

Filamentous bacteriophages for size, in vivo biodistribution and easiness of engineering, are considered as natural nanoparticles. The developed technology allows the construction of bio-nanoparticles based on filamentous bacteriophages delivering proteic antigens and immunomodulating lipids. Thanks to the high content of hydrophobic residues, phage capsid proteins have high binding affinity to lipids, allowing the conjugation of immunostimulating lipids.

Thematic areas
Health & Biotech
Health & Biotech / Nanomedicine
Health & Biotech / Development of new drugs
# Record card
49
Description

Celiac disease and non-celiac gluten sensitivity affect a large portion of the world population. Furthermore, the percentage of people who adopt the gluten free diet is constantly increasing because it is perceived to be healthier. We have previously developed a food grade enzymatic procedure (transamidation) for wheat flour capable of making gluten unable to induce the inflammatory response in the intestine of celiac disease patients.

Thematic areas
Health & Biotech / New therapies
Agrifood / Nutrition & health
# Record card
157
Description

The technology concerns planar optical antennas composed of thin metal films and dielectric materials for the efficient direction of the light emitted by light sources, such as fluorescent molecules and bio-markers. They consist of a reflector layer, adjacent to the substrate, and a director, semi-reflective, between which the emitter is positioned, integrated into a homogeneous dielectric layer.

Thematic areas
ICT & Electronics
ICT & Electronics / Sensor/multi-sensor technology, instrumentation
Chemicals & Physics
Chemicals & Physics / Micro and nanotechnology related to physical, chemical and exact sciences
Chemicals & Physics / Quantum optics
Chemicals & Physics / Radiometry, photometry and vision
Chemicals & Physics / Atomic and molecular spectroscopy
Agrifood
Agrifood / Nutrition & health
Agrifood / Food quality & safety
Automotive transport and logistics
Health & Biotech
Health & Biotech / Biosensors
Health & Biotech / Diagnostic kits
Energy and environmental sustainability
Energy and environmental sustainability / Sensory
# Record card
174
Description

Plants can compete favorably with traditional expression systems (mammalian cells, yeasts or bacteria) to produce recombinant proteins/peptides of pharmaceutical/industrial/agrifood interest. This technology names “Plant Molecular Farming”. The CNR-IBBA research team offers the study of new strategies for the expression and optimization of recombinant proteins/peptides in plant-based systems (plant tissues, transgenic plants, plant cell culture). Our pipeline is based on the following modules:

Thematic areas
Agrifood
Agrifood / Nutrition & health
Health & Biotech
Health & Biotech / Development of new drugs
Health & Biotech / Regenerative Medicine
# Record card
140
Description

The technology refers to an innovative plasma (ionized gas) source operating at atmospheric pressure and low electric power levels. A cold plasma is produced, characterized by an ion temperature significantly lower than the electron temperature. Partial ionization of a Helium flux is induced by a time-varying electric field in between two parallel grids, both perpendicular to the flux itself.

Thematic areas
Health & Biotech
Health & Biotech / Bio-medicals
Health & Biotech / Care, Hygiene, Cosmetics
Health & Biotech / New therapies
Health & Biotech / Medical Device
Chemicals & Physics
Chemicals & Physics / Cold Plasmas
# Record card
76
Description

The platform allows acquisition of data from commercial and custom sensors. By now, the system has been embedded in a wearable wristband where elastomeric based strain gauge have been integrated to detect fine hand/wrist/arm movements. The platform integrates inertial sensors (accelerometers, gyroscopes) to acquire more details about the subject movements. A sensor-fusion algorithm enables advanced movement recognition (gesture, 3D orientation). A machine-learning algorithm is in development to increase the performance of the platform.

Thematic areas
Health & Biotech / Smart Devices for Health and Wellness
ICT & Electronics / Internet of Things
ICT & Electronics / Electronics and microelectronics
ICT & Electronics / Information processing, information system, workflow management
# Record card
260
Description
Thematic areas
Agrifood
Agrifood / Nutrition & health
Agrifood / Food quality & safety
Health & Biotech
Health & Biotech / Development of new drugs
Additive and advanced industrial manufacturing
Health & Biotech / Biosensors
Health & Biotech / Bio-medicals
Chemicals & Physics
Additive and advanced industrial manufacturing / Packaging
Chemicals & Physics / Agro chemicals
Additive and advanced industrial manufacturing / Additive manufacturing processes and materials
Health & Biotech / Diagnostic kits
Chemicals & Physics / Colours & dyes
Chemicals & Physics / Plastics & rubber
Chemicals & Physics / Detergents & cleaning technologies
# Record card
50
Description

This technology describe the synthesis of cross-linked polymeric materials in the form of macroporous gels based on poly (2-hydroxyethyl methacrylate), capable of sequestering the anticoagulant heparin from aqueous solutions, physiological solutions and biological fluids. They are morphologically elastic and mechanically stable materials, and show high specificity and selectivity for heparin as demonstrated by the negligible adsorption of specific blood proteins such as antithrombin III, albumin and total proteins.

Thematic areas
Chemicals & Physics / Separation technologies
Health & Biotech / Medical Device
Materials / Plastics, polymers
# Record card
32
Description

The full face mask adapts to the face of the user; it is used in the medical field where there may be close contact between a patient and a doctor and in all those areas of possible social overcrowding that, in case of a pandemic, may lead to the spread of a virus. To date, as the main means of containment and prevention of infection, are used masks made of fabric or equipped with filter that adhere to the face of the user in order to shield nose and mouth and / or filter the air inhaled and / or exhaled by the user.

Thematic areas
Health & Biotech / Medical Device