Technologies

In this section it is possible to view, also through targeted research, the technologies inserted in the PROMO-TT Database. For further information on the technologies and to contact the CNR Research Teams who developed them, it is necessary to contact the Project Manager (see the references at the bottom of each record card).

Displaying results 1 - 15 of 57

# Record card
173
Description

Organotypic models of ovarian cancer are 3D models containing defined extracellular matrices, such as collagen and fibronectin, ovarian cancer cells with specific genetic/molecular characteristics, and one or more cancer-associated stromal cell types (fibroblasts, mesothelial cells, endothelial cells) to mimic specific metastatic niches of ovarian cancer (omentum, peritoneum, interstitial stroma) and the complex interactions within tumor tissues.

Thematic areas
Health & Biotech
Health & Biotech / Bio-medicals
Health & Biotech / Development of new drugs
# Record card
244
Description

The Proof-of-Concept A.L.I.C.E. or "Actuators based on Light sensitive CompositE" aims at the development of innovative materials through 3D/4D printing processes and uses them as actuators in the fields of photovoltaics, concentrated solar power, thermodynamic solar, and other applications such as optical deflectors, optical microvalves, and optical switches.

Thematic areas
ICT & Electronics
ICT & Electronics / Laser technologies
ICT & Electronics / Sensor/multi-sensor technology, instrumentation
ICT & Electronics / Optics & Acoustic
ICT & Electronics / Robotics and control systems
ICT & Electronics / Optoacustic sensors, Optoelectronic devices
ICT & Electronics / Nanotechnologies related to electronics and microelectronics
Additive and advanced industrial manufacturing
Materials
Materials / Composite and hybrid materials
Materials / Optical materials
Materials / Plastics, polymers
Materials / Processes of production & treatment of materials
Materials / Photo-active & graphene-based materials
Energy and environmental sustainability
Health & Biotech
# Record card
12
Description

Current standard SPECTs, in order to achieve high resolutions, use a multi-pinholes technology that requires numerous data processing to limit the effects of image distortion. The proposed SSR-SPECT scanner, uses a parallel-hole collimator and therefore does not require numerical reprocessing of the data to obtain correct information on the images, while assuring spatial resolutions close to those of the pinholes through the acquisition of sequences of images shifted from one to another.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
# Record card
161
Description

AIDD is an integrated tool and a radically new way to discovery new drugs for neurodegenerative diseases (Alzheimer’s, Epilepsy, Ageing, etc.).

Thematic areas
Health & Biotech
Health & Biotech / Bio-informatics
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Development of new drugs
Energy and environmental sustainability
Energy and environmental sustainability / Simulation
# Record card
98
Description

Leishmaniasis is a zoonosis caused by the protozoan of the genus Leishmania, which affects both humans and animals through a phlebotomist. After malaria and lymphatic filariasis, leishmaniasis is the third most common disease on a global scale. Leishmania infantum is the species spread in the European continent and the Mediterranean basin. In Italy, from the hilly coastal areas and major islands, the infection has spread to many pre-Alpine areas and northern Italy.

Thematic areas
Energy and environmental sustainability / Ecology & Biodiversity
Energy and environmental sustainability / Renewable sources
Bioeconomy
Chemicals & Physics / Organic substances
Health & Biotech / New therapies
Health & Biotech / Development of new drugs
# Record card
284
Description

This innovative technology involves the use of a high-affinity, highly specific antibody that targets extracellular domains of connexin hemichannels (Cx26, Cx30, and Cx32). The antibody has been designed to reduce or inhibit the growth of brain tumors, particularly glioblastoma (GBM), and to alleviate the associated epilepsy. By blocking connexin hemichannels, the antibody interferes with pathological ATP release and other signaling mechanisms that contribute to tumor progression and neural hyperexcitability.

Thematic areas
Health & Biotech
Health & Biotech / New therapies
Health & Biotech / Development of new drugs
# Record card
83
Description

Aptamers, short structured single-stranded oligonucleotides binding at high affinity to a given target protein, are selected from large combinatorial libraries through repeated cycles of incubation of the library with the target, recovery and amplification of target-bound oligonucleotides (SELEX technology, Systematic Evolution of Ligands by EXponential enrichment). SELEX can be applied to select aptamers against a known target protein or against a specific cell phenotype, without any prior knowledge of the specific target, leading to new biomarkers discovery.

Thematic areas
Health & Biotech / Micro and nanotechnology related to biological sciences
Health & Biotech / Bio-medicals
Health & Biotech / New therapies
Health & Biotech / Diagnostic kits
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Nanomedicine
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Development of new drugs
Health & Biotech / Biosensors
# Record card
80
Description

Time-correlated single photon counting (TCSPC) is regarded as the “gold-standard” method for fluorescence lifetime measurements. However, TCSPC requires using highly sensitive detectors, not suitable for measurements under bright light conditions, thereby making the use impractical in clinical settings. The invention described here solves this problem by synchronizing the fluorescence detection with an external light source.

Thematic areas
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
Health & Biotech / Biosensors
Health & Biotech / Bio-medicals
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic kits
Health & Biotech / Bio-informatics
# Record card
25
Description

The Biocrystal Facility, a large multidisciplinary laboratory established at the Institute of Molecular Biology and Pathology (IBPM) of CNR, in collaboration with the Biochemistry Department of Sapienza University aims at supporting the italian scientists and the pharmaceutical companies in the research to find new drug and vaccine against the endemic and epidemic diseases through structure-based drug design.

Thematic areas
Health & Biotech / Bio-informatics
Health & Biotech / Nanomedicine
Health & Biotech / Development of new drugs
# Record card
298
Description

C-ImmSim is one of the most advanced computational models of the immune system. The software resorts to (bit or amino acid) strings to represent the “binding site” of cells and molecules. C-ImmSim is an agent-based model that includes the major classes of immune cells of the lymphoid lineage and some of the myeloid lineage. Helper T cells are divided into five phenotypes. B cells and plasma B are also divided into two phenotypes.

Thematic areas
Health & Biotech / New therapies
Health & Biotech / Bio-informatics
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Development of new drugs
# Record card
27
Description

The dramatic global health emergency due to the SARS-CoV-2 pandemic requires new diagnostic devices capable of identifying the presence of virus particles in patient biological samples. In this direction, the development of an innovative low-cost test, which provides the result within a few minutes, which is reproducible and which can reveal the direct presence of even a few viral particles, would be of fundamental importance for the monitoring and containment of the pandemic.

Thematic areas
Health & Biotech / Micro and nanotechnology related to biological sciences
ICT & Electronics / Sensor/multi-sensor technology, instrumentation
Health & Biotech / Bio-medicals
Health & Biotech / Diagnostic kits
ICT & Electronics / Big Data
Health & Biotech / Smart Devices for Health and Wellness
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
Health & Biotech / Biosensors
# Record card
26
Description

The final technology will add polarimetric capability to imaging cameras in the NUV/optical, providing simultaneous measurements of the different polarization states of the light. This will be obtained by the development of an innovative coating based on nanostructured emissive materials sensitive to the polarization of the incident light. A  double layer film of two organic systems will be coupled to image detectors so that the two polarization components of the incoming light are converted into two different colors.

Thematic areas
Aerospace and Earth Science / Satellite technologies
Materials / Optical materials
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
# Record card
69
Description

The aim of the present invention is to develop a modular scintigraphic device, with high spatial resolution, capable of creating investigation areas of various shapes and sizes, of compact form and of being used in different types of applications.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
# Record card
42
Description

The present invention relates to a gamma camera for intracavitary use, which is widely used in the field of radio-guided surgery (intra-operative and laparoscopic and robotic-assisted) for the localisation of lymph nodes and tumours and/or other pathologies. The aim of the present invention is to make available an intraoperative tool able to overcome the drawbacks of the present known art.

Thematic areas
Health & Biotech / Bio-medicals
Health & Biotech / Medical imaging & equipment
Health & Biotech / Diagnostic, Medical imaging & advanced bioimaging
Health & Biotech / Medical Device
# Record card
150
Description

The virtual dynamic docking, carried out in the MOLBD3 lab of the Institute of Biophysics, allows the identification of new drugs through the structural information deriving from the study of target proteins, responsible for some human pathologies. In particular, we screen drugs or small molecules (commercial/own libraries) against known protein sites, surface cavities, surfaces of protein-protein interactions (fixed/rigid hotspots) or structural transition states (dynamic hotspots).

Thematic areas
Health & Biotech
Health & Biotech / Development of new drugs
Health & Biotech / Bio-medicals
Health & Biotech / Bio-informatics