Oral hypoglycemic pharmaceutical preparation containing a metallic compound and plant extracts derived from waste biomass

# Record card
295
Thematic areas
Agrifood / Nutrition & health
Health & Biotech / Development of new drugs
Description

Our proposal focuses on innovative formulations containing metallic complexes and plant extracts for diabetes treatment. The formulations were tested in vitro on human adipocyte cell models, showing a strong hypoglycemic effect due to the synergistic action of the two components. The plant extracts, derived from waste biomass of the agri-food industry, possess high antioxidant activity and interesting nutraceutical properties, due to their composition rich in polyphenols. Tests conducted on colon fibroblast cells demonstrated that the extracts significantly decrease the intestinal toxicity associated with metallic compounds when administered together. The combination of the two components has led to the development of highly effective and low-toxicity formulations, decreasing the required doses of the metal and, consequently, the side effects that could limit their therapeutic application.

Type of innovation
Product innovation
Description of innovative features / Competitive advantages

The high hypoglycemic activity combined with low toxicity and the advantage of oral administration make these formulations promising candidates for preclinical and clinical studies aimed at evaluating their efficacy as potential antidiabetic drugs. A distinctive aspect is given by the combination of the effects of the metal compound and plant extracts on glycemic control, that allows to intervene on multiple causal factors of diabetes. Furthermore, the chemical composition of the extracts, rich in bioactive components, suggests a possible use also in the nutraceutical field, expanding their potential applications. An important added value lies in the use of waste biomass from the agri-food industry to produce plant extracts. This aspect responds to the need of companies interested in implementing entrepreneurial strategies oriented towards the circular economy, promoting economic development and environmental sustainability.

Reference market
Impacts on existing markets
Development stage
Feasibility
TRL
3
Advantages
Cost reduction
Patentable technology
Yes
Patented technology
Yes
Country/ies

Italy

Publication of technology
No
Technology validation/demonstration
Internal validation
Market positioning
Italian
Partner required
Enteprise
Public research center/university
Private research center
Seed capital
Cooperation in national /european / international project

Information
For more information and/or to be put in contact with the Research Team, please contact the Project Manager:

Barbara Angelini - Project Manager
CNR - Unità Valorizzazione della Ricerca
Phone number 06.49932415
E-mail barbara.angelini@cnr.it